Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07277517

The Effect of Integrating Pain Neuroscience Education(PNE) With Conventional Physiotherapy on Pain and Functional Disability in Patients With Acute Low Back Pain

Led by Iran University of Medical Sciences · Updated on 2026-04-03

48

Participants Needed

1

Research Sites

42 weeks

Total Duration

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AI-Summary

What this Trial Is About

Acute low back pain is one of the most common health problems in the world. Most people experience it at least once in their lives, and although many cases improve within a few weeks, a significant number of patients continue to struggle with pain, fear of movement, stress, and reduced daily function. These psychological factors-such as catastrophizing ("my back is damaged"), fear of movement ("if I move, it gets worse"), and avoidance behaviors-can slow recovery and increase the risk of the pain becoming chronic. Pain Neuroscience Education (PNE) is a modern educational approach that teaches patients how pain actually works in the nervous system. Instead of focusing only on muscles and bones, PNE helps people understand how the brain interprets pain, why pain can persist even without serious injury, and how thoughts, emotions, and behaviors can influence the experience of pain. Research shows that PNE can reduce fear, improve movement, and help people participate better in rehabilitation-especially in chronic pain. However, there is very limited high-quality evidence about its effects in acute low back pain. The purpose of this study is to determine whether adding Pain Neuroscience Education to routine physiotherapy can improve recovery in people with acute low back pain. To do this, the investigators will conduct a single-blind randomized clinical trial with two groups of patients: Control group: Receives conventional physiotherapy, including soft-tissue mobilization and TENS, along with routine patient education about posture and back care. Intervention group: Receives the same physiotherapy plus two structured sessions of Pain Neuroscience Education, delivered individually using simple explanations, metaphors, and visual materials. Both groups will receive eight treatment sessions over four weeks. The investigators will measure several important outcomes before starting treatment and immediately after the 8th session, including: Pain intensity Functional disability Pain catastrophizing Fear-avoidance beliefs Fear of movement (kinesiophobia) The investigators' hypothesis is that patients who receive PNE in addition to routine physiotherapy will show greater reductions in pain, disability, fear, and catastrophizing compared to those receiving physiotherapy alone. If proven effective, this approach could provide a simple, low-cost, and safe addition to physiotherapy that not only reduces pain but also prevents acute low back pain from turning into a chronic condition. This could help improve patients' quality of life and reduce the economic and healthcare burden caused by low back pain.

CONDITIONS

Official Title

The Effect of Integrating Pain Neuroscience Education(PNE) With Conventional Physiotherapy on Pain and Functional Disability in Patients With Acute Low Back Pain

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 years and older
  • Primary complaint of acute low back pain between the bottom of the ribs and the gluteal fold, with or without leg pain
  • Pain duration less than 6 weeks
  • No signs of serious spinal problems (like tumor, infection, fracture, cauda equina syndrome) confirmed by a specialist
Not Eligible

You will not qualify if you...

  • Low back pain lasting more than 3 months (chronic low back pain)
  • Spinal surgery within the past 3 years
  • Unable to read or understand Persian
  • Diagnosed cognitive impairments
  • Unwilling to continue treatment or study protocol
  • Diagnosed rheumatic, neurological, cardiac, metabolic, or respiratory diseases
  • Diagnosis of fibromyalgia, chronic fatigue syndrome, loss of skin sensation, or skin inflammation/swelling in the low back area
  • Presence or development of any serious spinal condition (red flags)
  • Missing more than 3 consecutive treatment sessions
  • Previous participation in Pain Neuroscience Education sessions

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

rehabilitation facility, Iran university of medical science

Tehran, Iran

Actively Recruiting

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Research Team

M

Mohammadreza Pourahmadi

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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