Actively Recruiting
Effect of Intensive LDL-cholesterol Targeting for Elderly Patients With Cardiovascular Disease: I-OLD Trial
Led by Yonsei University · Updated on 2024-03-15
1200
Participants Needed
1
Research Sites
273 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Although there have been studies regarding intensive lowering of low-density lipoprotein (LDL)-cholesterol with high intensity statins in patients with cardiovascular disease, elderly patients were either excluded or accounted only a small portion of study subjects. Therefore, this study sought to compare the clinical outcomes according to the LDL-cholesterol therapy targeting (intensive targeting \[LDL-cholesterol \<55mg/dL\] vs. conventional therapy \[moderate intensity statin therapy\]) in elderly patients with ≥75 years and documented cardiovascular disease.
CONDITIONS
Official Title
Effect of Intensive LDL-cholesterol Targeting for Elderly Patients With Cardiovascular Disease: I-OLD Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 75 years or older
- Documented cardiovascular disease including at least one of the following: previous acute coronary syndrome (heart attack or unstable angina), stable angina confirmed by imaging or functional tests, coronary revascularization, or peripheral artery disease
You will not qualify if you...
- Heart attack or stroke within the past year
- LDL-cholesterol level less than 55 mg/dL without statin therapy
- Active liver disease or persistent unexplained liver enzyme elevation more than twice the upper normal limit
- Allergy or hypersensitivity to any statin
- Life expectancy less than 1 year
- Inability to follow the patient for at least 1 year after enrollment as assessed by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yonsei University Health System, Severance Hospital
Seoul, South Korea
Actively Recruiting
Research Team
B
Byeong-Keuk Kim
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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