Studying Intermittent Theta Burst Stimulation to Reduce Pain and Improve Brain Function in Older Adults with Chronic Musculoskeletal Pain

What this Trial Is About

Researchers are investigating the effects of accelerated intermittent Theta Burst Stimulation iTBS on pain relief and cognitive function in older adults aged 60 to 85 who suffer from chronic musculoskeletal pain. This study also uses magnetic resonance imaging MRI to explore the brain mechanisms that might explain how iTBS influences these outcomes. The trial aims to determine if stimulating the left dorsolateral prefrontal cortex with accelerated iTBS is effective for this population and to understand the underlying neurophysiological changes. Participants will receive treatment using a device called the Cool-6000 AP coil, which delivers real or sham iTBS to the scalp. Each day, participants will have two iTBS sessions spaced 15 minutes apart, with each session lasting about 30 minutes. The stimulation protocol includes 1,200 pulses per day over a total of 14 days, with an intensity set at 70% of the resting motor threshold. This study is randomized, with participants assigned to either real iTBS or sham control groups. Throughout the study, participants will undergo MRI scans before and immediately after the treatment period. They will also complete various tests measuring cognitive function and pain before, right after treatment, and at follow-up intervals including one, three, and six months post-treatment. Researchers will assess outcomes such as pain intensity, cognitive abilities, depression, anxiety, physical activity, sleep quality, and frailty. Safety and acceptability of the iTBS treatment will also be monitored, with the entire participation lasting up to six months for follow-up assessments.

The Effect of Intermittent Theta Burst Stimulation on Brain Characteristics, Pain Intensity, and Cognitive Functions in Older People with Chronic Musculoskeletal Pain.