Actively Recruiting
Effect of Interval Aerobic Training and Mindfulness Breathing on Hormonal, Metabolic, and Tumor Markers in Postmenopausal
Led by Cairo University · Updated on 2024-09-04
60
Participants Needed
1
Research Sites
279 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
PURPOSE: to determine the effect of interval training and mindfulness breathing on sex hormones, metabolic and tumor markers BACKGROUND: Cancer is one of death top causes in many countries1. In Egypt for example, cancer incidence is 157.0 per 100 000 women with probability increasing up to three-fold by 2050 especially in older adult women2. Who exhibit multiple factors leading to cancer including but not limited to physical inactivity and postmenopausal obesity which considered the starting point of developing insulin resistance3. High blood insulin level stimulates cancer progression by enhancing cell proliferation, decreasing cells apoptosis, increased level of fatty acids in conjunction with higher tumor cell formation capacity invasion and survival4. Moreover, high level of insulin resistance and adipose tissue increase the hormonal level of estradiol and testosterone coupled with lower SHBG level. It was noticed that being postmenopausal women with high adipose tissue content will increase the risk of having cancer in which adipose tissue is considered as the main source of steroids hormones that functioning in a different way rather than in premenopausal age. Based on the mentioned underlying conditions, postmenopausal women subjected to have variable types of cancer such as breast, endometrial, stomach, etc6. So, regular screening of cancer incidence especially in high-risk women through tumor indicators is necessitated to work against further cancer progression. CEA and CA125 are low-cost tumor blood biomarkers used widely for early cancer identification, recurrence monitoring and follow up which linked to proinflammatory cytokines production . HYPOTHESES: may have no effect to interval training and mindfulness breathing on sex hormones , metabolic and tumor markers in postmenopausal women RESEARCH QUESTION: Is there effect to interval training and mindfulness on sex hormones , metabolic and tumor markers in postmenopausal women?
CONDITIONS
Official Title
Effect of Interval Aerobic Training and Mindfulness Breathing on Hormonal, Metabolic, and Tumor Markers in Postmenopausal
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 55 to 65 years
- Postmenopausal for more than 2 years
- Body mass index (BMI) between 35 and 39.9 kg/m2
You will not qualify if you...
- Receiving weight-reduction interventions
- Taking lipid-lowering drugs
- Taking regular medications such as beta-blockers, alpha-blockers, digoxin, diuretics, aspirin, nitrates, or sex hormones
- Having active chronic illnesses like rheumatoid arthritis, hyperthyroidism, inflammatory bowel disease, diabetes mellitus, or unstable endocrine diseases
- Cognitive impairment affecting participation
- Presence of malignant disease
- Donated blood within the last 30 days
- Participated in any study or research in the last 90 days
- Smoking
AI-Screening
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Trial Site Locations
Total: 1 location
1
Physical Therapy
Cairo, Egypt, 11432
Actively Recruiting
Research Team
M
marwa m elsayed, phd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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