Studying Moderate Intensity Interval Exercise to Improve Function in Veterans with COPD and Obstructive Sleep Apnea

What this Trial Is About

Researchers are studying Veterans who have both chronic obstructive pulmonary disease COPD and obstructive sleep apnea OSA, a condition known as Overlap Syndrome OS. These patients often experience premature aging and functional decline earlier than others. The study aims to evaluate functional outcomes in three areas participation in daily life, physical activity, and cardiovascular health, with the goal of developing an exercise strategy to reduce functional decline in these Veterans. Participants in this randomized trial will either engage in a novel moderate intensity interval training MIIT program consisting of 5-minute exercise intervals at 50% VO2peak, done three times a week for 12 weeks, or continue with their usual care by maintaining their regular activity level. The MIIT intervention is designed to fit the needs and abilities of Veterans with excessive daytime sleepiness related to Overlap Syndrome. During the study, participants will be assessed on measures such as daytime sleepiness using the Epworth Sleepiness Scale, daily step counts, and levels of serum hs-CRP, an inflammation marker, all evaluated after 12 weeks. The study includes monitoring physical activity and functional status, with the aim of understanding how the exercise intervention affects these outcomes over the trial period.

The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA