Actively Recruiting
Effect of an Intervention to Prevent Acute Kidney Injury Versus Standard Care in High-risk Patients After Major Surgery
Led by University Hospital Muenster · Updated on 2024-08-01
480
Participants Needed
1
Research Sites
140 weeks
Total Duration
On this page
Sponsors
U
University Hospital Muenster
Lead Sponsor
B
Baxter Healthcare Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
There is no specific therapy for acute kidney injury. It is presumed that supportive measures improve the care and outcome of patients with acute kidney injury. To investigate whether an implementation of a supportive extended care "bundle" in high-risk patients for persistent acute kidney injury (AKI) can reduce the occurrence of persistent surgical AKI. In order to investigate whether the extended KDIGO bundle can prevent persistent AKI in patients with high chemokine ligand 14 (CCL14) as well as in patients with low CCL14, patients will be randomized with stratification by the CCL-value.
CONDITIONS
Official Title
Effect of an Intervention to Prevent Acute Kidney Injury Versus Standard Care in High-risk Patients After Major Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (age 5318 years)
- Moderate or severe AKI (defined by the 2012 KDIGO criteria, KDIGO stage 2 and 3), determined by either serum creatinine or urine output, within 72 hours after a surgical procedure
- Written informed consent
You will not qualify if you...
- Dialysis-dependent chronic kidney disease
- Prior kidney transplant
- Infections with human immunodeficiency virus or hepatitis
- Hepatorenal syndrome
- Pregnancy or breast-feeding
- Participation in another interventional trial that investigates a drug that affects kidney function within the last 3 months
- Persons held in an institution by legal or official order
- Persons with any kind of dependency on the investigator or employed by the responsible institution or investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Münster; 1Department of Anesthesiology, Intensive Care Medicine and Pain Medicine
Münster, Germany
Actively Recruiting
Research Team
Z
Zarbock, MD
CONTACT
M
Meersch, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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