Actively Recruiting
Effect of an Intervention Program of Adapted Physical Activity Combined With Compensatory Nutrition in Patients With Constitutional Thinness
Led by Centre Hospitalier Universitaire de Saint Etienne · Updated on 2025-10-07
62
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire de Saint Etienne
Lead Sponsor
L
Laboratoire Interuniversitaire de Biologie de la Motricité
Collaborating Sponsor
AI-Summary
What this Trial Is About
Constitutional Thinness (CT) is a form of stable thinness without malnutrition but with resistance to weight gain, affecting approximately 1% of the general population. The clinical consequences are numerous and the pathophysiology remains poorly understood. Currently, conventional management involves a high-calorie and frequent diet, combined with the avoidance of endurance physical activity, although there is no significant evidence of its effectiveness. Our hypothesis is that an adapted physical activity program (APA) combined with compensatory nutrition (CN) could help these patients gain lean mass (muscle mass).
CONDITIONS
Official Title
Effect of an Intervention Program of Adapted Physical Activity Combined With Compensatory Nutrition in Patients With Constitutional Thinness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female gender
- Body Mass Index (BMI) of 18.5 kg/m2 or less
- Stable body weight for at least 3 months
- Age between 18 and 50 years at the time of inclusion
- Diagnosed with Constitutional Thinness
You will not qualify if you...
- Pregnancy, childbirth, or breastfeeding
- Being deprived of liberty, involuntarily hospitalized, hospitalized for non-research reasons, under legal protection, or unable to consent
- Presence of eating disorders meeting DSM IV or DSM 5 criteria
- Consuming more than 10 glasses of wine equivalent per week
- Having severe progressive medical conditions such as diabetes
- Engaging in intense physical activity more than 3 times per week
- Smoking more than 10 cigarettes per day
- Having depressive or psychiatric conditions requiring antidepressant or psychotropic treatment
- Medical or surgical history considered incompatible with the study by the investigator
- Contraindications to MRI preventing spectro-MRI analyses
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CHU de Saint-Etienne
Saint-Etienne, France, France, 42055
Actively Recruiting
Research Team
N
Natacha GERMAIN, PhD
CONTACT
F
Florence RANCON, Cheffe de projet
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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