Comparing Two Doses of Intranasal Dexmedetomidine to Reduce Agitation in Children Ages 3 to 6 Undergoing Eye Muscle Surgery

What this Trial Is About

This research aims to compare the effects of two different doses of intranasal dexmedetomidine on the incidence of emergence agitation in children undergoing strabismus surgery. Emergence agitation, or delirium, is a common problem in young patients after general anesthesia for eye muscle surgery, causing confusion, crying, and uncooperative behavior during recovery. This study focuses on children aged 3 to 6 years and investigates whether a higher dose of dexmedetomidine can reduce this agitation more than a lower dose. Participants are randomly assigned to receive either 3 mcgkg or 2 mcgkg of intranasal dexmedetomidine 45 minutes before surgery using a nasal atomizer device. The surgery is performed under general anesthesia with standard medications including sevoflurane and fentanyl. Monitoring during surgery includes blood pressure, heart rate, oxygen levels, and breathing. The study is double-blind and randomized, ensuring unbiased comparison between the two dose groups. During the study, children are assessed for emergence agitation using the Pediatric Anesthesia Emergence Delirium PAED scale. Other measures include heart rate and blood pressure changes during surgery, pain scores after surgery, anxiety before surgery using the Modified Yale Preoperative Anxiety Scale, and time spent in the post-anesthesia care unit. The study involves preoperative evaluation, careful monitoring during surgery, and follow-up after surgery to record these outcomes. Participation lasts through the surgery day and immediate recovery period.

Effect of Intranasal Dexmedetomidine on the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery