Actively Recruiting
Effect of Intrauterine Administration of Autologous PBMC Modulated With IFNt on IVF Outcome
Led by Nadezhda Women's Health Hospital · Updated on 2025-05-21
300
Participants Needed
1
Research Sites
164 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to test the effect of modulated specialised immune cells isolated from the patients' own blood when administered to the uterus before embryo transfer on the IVF outcome (implantation, pregnancy and live birth rates). To achieve this, blood will be obtained from eligible participants. Target cells will be isolated and incubated with the tested modulator for 24h, and returned to the uterine cavity 1 day prior to embryo transfer. Researchers will compare the reproductive outcome of the tested intervention to that of a control group who will not receive the investigated cell treatment prior to embryo transfer.
CONDITIONS
Official Title
Effect of Intrauterine Administration of Autologous PBMC Modulated With IFNt on IVF Outcome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participating in Assisted Reproduction Treatment
- Having primary infertility
- Having regular menstrual cycles
- Scheduled to undergo embryo transfer of euploid embryos only
You will not qualify if you...
- Uterine pathologies
- Endometrial bacterial infections
- Active endometrial inflammation
- Polycystic ovary syndrome
- Presence of auto antibodies such as anti-TPO (thyroid peroxidase), anti-TG (thyroglobulin), ACA (anticentromere antibodies), APA (antiphospholipid antibodies), ANA (antinuclear antibodies), and anti-dsDNA
- Presence of mutations involving the coagulation system such as deficiency of factor XII, Pro C, Pro S
- Oncological condition
- Positive HIV (human immunodeficiency virus), HCV (hepatitis C virus) or HBV (hepatitis B virus) tests
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Nadezhda Women's Health Hospital
Sofia, Sofia, Bulgaria, 1330
Actively Recruiting
Research Team
D
Dimitar Parvanov, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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