Actively Recruiting

Phase 4
Age: 18Years +
FEMALE
NCT07131592

Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

Led by Massachusetts General Hospital · Updated on 2026-01-16

160

Participants Needed

1

Research Sites

93 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study aims to evaluate whether tranexamic acid (TXA), a medication that helps reduce bleeding, can decrease fluid drainage after breast reduction surgery. Participants will be randomly assigned to receive either intravenous TXA or no TXA during surgery. Additionally, one breast will receive TXA through the surgical drain, while the other will receive saline. This approach allows to compare the effects of TXA on fluid buildup and healing. The goal is to improve recovery and reduce complications after breast reduction surgery.

CONDITIONS

Official Title

Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

Who Can Participate

Age: 18Years +
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 years or older
  • Elective bilateral breast reduction
  • Patient understands and is willing to participate in the study
  • Patient willing to and capable of providing informed consent
Not Eligible

You will not qualify if you...

  • Age less than 18 years old
  • Prior radiation to the breast
  • Secondary/Revision breast reduction
  • Known coagulopathy or bleeding disorders
  • Intraoperative coagulopathy
  • History of seizures
  • Active smokers
  • Allergy or contraindication to TXA
  • Pregnant or breastfeeding patients
  • Patient is unable or unwilling to complete the anticipated study follow-up
  • Inability to understand the aims and objectives of the study
  • Inability to or unwilling to provide informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Massachusetts General Hospital

Boston, Massachusetts, United States, 02114

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery | DecenTrialz