Study of Intrawound Vancomycin Powder Use to Prevent Infection After Spine Surgery A Randomized Controlled Trial

What this Trial Is About

Postoperative wound infections after spinal surgeries are a serious concern due to their high occurrence, increased healthcare costs, longer hospital stays, and reduced quality of life. Various methods have been used to prevent these infections, including betadine irrigation, vacuum-assisted closure, and intra-wound vancomycin powder. This trial aims to evaluate the effect of applying intrawound vancomycin powder during spinal surgery to reduce the rate of post-surgical infections. Participants will be randomly assigned to one of two groups one group will receive intrawound vancomycin powder during surgery, while the control group will not receive this intervention. The amount of vancomycin powder applied depends on the number of surgical levels involved, ranging from 500 mg to 2 grams. All patients will receive standard systemic antibiotic prophylaxis, and the study will use a single-blind design where patients are unaware of their group assignment. Participants will be monitored for 12 weeks after surgery to detect wound infections and other complications, including those related to vancomycin use. Data collected include patient demographics, comorbidities, surgical details, and infection outcomes. The primary outcome is the rate of infection within three months, and secondary outcomes include other complications during this period. The study will also record cultured organisms and treatments administered for infections.

The Effect of Intrawound Vancomycin Powder in Spine Surgery