Actively Recruiting
Effect of Itopride on Semaglutide Gastroparesis
Led by Ain Shams University · Updated on 2025-11-28
60
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Semaglutide delays gastric emptying and increases the risk of aspiration with anesthesia; So, the addition of prokinetics as Itopride, could enhance gastric emptying and hasten surgery. The investigator will evaluate the effect of Itopride on Semaglutide-induced gastroparesis and residual gastric contents after 8 hours of fasting by gastric ultrasound before anesthesia.
CONDITIONS
Official Title
Effect of Itopride on Semaglutide Gastroparesis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 40 to 60 years
- American Society of Anesthesiologists grade I to III
- Body mass index between 20 and 30 kg/m2
- Diagnosed with type 2 diabetes and currently receiving Semaglutide (0.5-1mg) subcutaneously weekly
- Scheduled for elective hysterectomy
You will not qualify if you...
- Declined to give written informed consent
- History of upper abdominal surgery or presence of hiatal hernia
- Use of medications that can cause gastroparesis such as opioids, proton pump inhibitors, tricyclic antidepressants, calcium channel blockers, antipsychotic medications, or lithium
- History of allergy to Itopride
- History of cardiac arrhythmia or abnormal ECG
- Neurologic diseases including Parkinson's disease and multiple sclerosis
- Hepatic or renal failure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
faculty of medicine, Ain Shams University
Cairo, Cairo Governorate, Egypt, 11591
Actively Recruiting
Research Team
T
tamer Samir abdelaziz, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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