Actively Recruiting
Effect of Kidney Replacement Therapy with Polymethylmethacrylate Membranes on Pruritus-related Quality of Life in Patients Receiving Maintenance Haemodialysis
Led by Saint Petersburg State University, Russia · Updated on 2025-03-04
62
Participants Needed
1
Research Sites
35 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled trial aims to evaluate the effect of polymethylmethacrylate dialysis membranes use on the intensity of pruritus in patients with CKD stage 5D receiving maintenance hemodialysis. The main question it aims to answer is: Does the use of polymethylmethacrylate (PMMA) membranes reduce the intensity of pruritus in dialysis patients? Researchers will compare PMMA membranes to standard polysulfone-based membranes to see if PMMA works to reduce moderate-to-severe pruritis and pruritis-related quality of life. Participants will: * receive maintenance hemodialysis with PMMA or polysulfone membranes for 2 months; * fill in questionnaires about intensity of pruritis and its impact on daily life.
CONDITIONS
Official Title
Effect of Kidney Replacement Therapy with Polymethylmethacrylate Membranes on Pruritus-related Quality of Life in Patients Receiving Maintenance Haemodialysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of CKD stage 5D, with maintenance hemodialysis for at least 3 months before screening
- Moderate-to-severe pruritus with a WI-NRS score of 4 or higher
- Adequate dialysis dose (spKt/V 21 1.4 and/or eKt/V 21 1.2)
- Dialysis regimen of three sessions per week, each lasting at least 4 hours
- Signed informed consent
You will not qualify if you...
- Active skin disease, cholestasis, severe secondary hyperparathyroidism, or other conditions causing pruritus as judged by the investigator
- Patient noncompliance with the study protocol as judged by the investigator
- Current use of haemodiafiltration
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Saint Petersburg State University Hospital
Saint Petersburg, Russia, 198103
Actively Recruiting
Research Team
E
Ekaterina Parshina, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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