Actively Recruiting
Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With STEMI
Led by Ain Shams University · Updated on 2025-06-26
76
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study aims is to evaluate the efficacy and tolerability of L-Carnitine on biomarkers of myocardial reperfusion injury in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI by the assessment of nitrotyrosine as an oxidative stress marker and Matrix metallopeptidase-2 (MMP-2) as a cardiac fibrosis marker
CONDITIONS
Official Title
Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With STEMI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female or male aged >18 and < 75 years.
- STEMI patients undergoing PCI.
You will not qualify if you...
- Patients with a recent history of myocardial infarction (MI), a previous PCI, a previous coronary artery bypass graft, or any cardiac surgery.
- Late presentation (>12 hours) or unsuccessful primary PCI (residual stenosis >50% in the culprit lesion after procedure).
- Pretreatment with thrombolytic or glycoprotein IIb/IIIa inhibitor therapy before primary PCI.
- Concurrent infectious or active inflammatory disease.
- Severe liver or renal disease (AST or ALT > 3 times upper limit of normal, total bilirubin > 3 times upper limit of normal, or creatinine clearance < 60 ml/min).
- Neoplasm or hematological disorders.
- Pregnant or breast-feeding patients.
- Active participation in another clinical study.
- Patients taking antioxidant drugs.
- History of or known allergy or intolerance to the study medications.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ain Shams University Hospitals
Cairo, Egypt
Actively Recruiting
Research Team
M
Mohamed Hamdy Mohamedy
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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