Inhibitory effect of black tea, lemon juice, and other beverages on salivary and pancreatic amylases: What impact on bread starch digestion? A dynamic in vitro study.
Daniela Freitas, Steven Le Feunteun
https://pubmed.ncbi.nlm.nih.gov/31253299Actively Recruiting
Phase Not Applicable
Age: 18Years - 35Years
All Genders
Healthy Volunteers
ID07563985
The Effect of Lemon Juice and Apple Cider Vinegar on Postprandial Blood Glucose and Satiety in Healthy Individuals
Led by Alanya Alaaddin Keykubat University · Updated on 2026-05-04
15
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how consuming acidic drinks like lemon juice and apple cider vinegar with starchy foods affects blood sugar levels and feelings of fullness in healthy adults aged 18 to 35. The study aims to understand whether these drinks can slow the rise in blood sugar after meals, compare their effectiveness, and assess if different amounts change their impact. This research focuses on practical dietary choices that might help manage blood sugar and support metabolic health. Participants will consume white bread in the morning on an empty stomach alongside one of several drinks: plain water, water with either 50 g or 100 g of lemon juice, or water with 10 g or 20 g of apple cider vinegar. Each participant will have a one-week break between tests. The study uses a randomized design to compare the different acidic beverages and doses. During each test day, participants will have their blood sugar measured at regular intervals for three hours after eating. They will also report their feelings of fullness using a simple scale. Researchers will track post-meal blood glucose levels, including peak levels and total glucose response over time. The study includes measures of appetite and glucose increase rate to evaluate how these drinks affect digestion and satiety.
CONDITIONS
Brief Title
Effect of Lemon Juice and Apple Cider Vinegar on Postprandial Blood Glucose and Satiety in Healthy Individuals
Who Can Participate
Age: 18Years - 35Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Healthy male and female volunteers aged 18-35 years
- Body Mass Index (BMI) between 18.5 and 25.0 kg/m8
- Willingness to provide written informed consent
- Ability to comply with study procedures and fasting requirements
- No history of chronic metabolic, gastrointestinal, or endocrine diseases
You will not qualify if you...
- Presence of any chronic disease such as diabetes mellitus, cardiovascular disease, or gastrointestinal disorders
- Food allergies or intolerances to white bread, lemon juice, or apple cider vinegar
- Body Mass Index (BMI) less than 18.5 or greater than 25.0 kg/m8
- Regular participation in high-intensity physical activity 5 or more days per week
- Current or recent (past 3 months) smoking or smoking cessation
- Use of any medication or supplements affecting glucose metabolism
- History of eating disorders
- Pregnancy, lactation, or menopause
- Female participants currently in menstruation period (testing postponed during menstruation days)
- Alcohol consumption within 24 hours prior to testing days
- Caffeine intake or major dietary changes on the day before testing days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Multiple test days with a 1-week washout period between each intervention
Participants consume white bread along with different acidic beverages or plain water in a randomized crossover design to evaluate the effects on post-meal blood glucose levels and satiety.
5 test days with blood glucose and appetite assessments up to 180 minutes after each meal
Trial Site Locations
Total: 1 location
1
Alanya Alaaddin Keykubat University
Alanya, Antalya, Turkey (Türkiye), 07400
Actively Recruiting
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Research Team
E
Ezgi Toptaş Bıyıklı, Assistant Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
5
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Published Research Related To This Trial
Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects.
E Ostman, Y Granfeldt, L Persson...
https://pubmed.ncbi.nlm.nih.gov/16015276The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized controlled clinical trial.
Alireza Gheflati, Reihane Bashiri, Akram Ghadiri-Anari...
https://pubmed.ncbi.nlm.nih.gov/31451249Lemon juice, but not tea, reduces the glycemic response to bread in healthy volunteers: a randomized crossover trial.
Daniela Freitas, François Boué, Mourad Benallaoua...
https://pubmed.ncbi.nlm.nih.gov/32201919