Long-term Effects of Continuous Intravenous Lidocaine on Pain and Survival After Colorectal Cancer Surgery in Older Adults

What this Trial Is About

Researchers are evaluating the effects of a long-term infusion of lidocaine on postoperative chronic pain, quality of life, and survival among elderly patients undergoing colorectal cancer surgery. This study is a follow-up observation of patients previously enrolled in a related trial, focusing on how lidocaine impacts pain and survival over time. The goal is to better understand the long-term benefits and outcomes of using lidocaine in this surgical setting. Participants are randomly assigned to one of two groups the lidocaine group or the placebo group. Those in the lidocaine group receive a continuous infusion of lidocaine at a dose of 1.5 mgkgh during the surgery, followed by a postoperative analgesia pump containing lidocaine, sufentanil, and granisetron for 72 hours. The placebo group receives an equivalent volume of normal saline during surgery and a postoperative device with sufentanil and granisetron without lidocaine. The treatments are given under double-blind conditions. Participants will be followed from three months up to five years after surgery to assess chronic pain occurrence, the impact of pain on quality of life, and survival outcomes including relapse-free and overall survival. Researchers will use tools such as the Brief Pain Inventory to measure pain interference and monitor neuropathic pain prevalence. The study includes regular assessments and long-term follow-up to understand the lasting effects of lidocaine infusion on recovery and survival.

Effect of Lidocaine on Postoperative Pain and Long-term Survival in Elderly Patients Undergoing Colorectal Surgery