Study Comparing Adjusted vs Standard Limb Lengths in Roux-en-Y Gastric Bypass Surgery for Morbid Obesity

What this Trial Is About

Researchers are conducting a randomized controlled trial to compare two types of Roux-en-Y gastric bypass RYGB surgeries for morbid obesity. The trial evaluates a surgery where biliopancreatic BP and roux limb lengths are adjusted to 30% and 15% of the patients total small bowel length aRYGB versus the current standard approach using fixed 100 cm limb lengths sRYGB. The study aims to understand if adjusting limb lengths improves weight loss and metabolic outcomes, such as diabetes, hyperlipidemia, and hypertension resolution, while also assessing postoperative quality of life. Participants will be randomly assigned to either the standard RYGB group with fixed limb lengths or the ratio-adjusted RYGB group with limb lengths based on individual bowel measurements taken during surgery. The trial follows patients with scheduled assessments at 6, 12, 24, and 60 months after surgery to measure weight loss, diabetes status, metabolic syndrome effects, vitamin and nutritional levels, and quality of life using validated surveys. During the study, patients will have routine follow-ups every 6 months for the first two years, then yearly thereafter, including weight and BMI measurements, blood tests for metabolic markers, and quality of life questionnaires. Researchers will track complications, adverse events, and any additional bariatric surgeries. The main measure is total weight loss at designated time points, alongside secondary outcomes like diabetes resolution and metabolic improvements, with the total study duration extending up to five years post-surgery.

Effect of Limb Length Ratio on Roux-en-Y Gastric Bypass Outcomes (CLIMB II Study)