Randomized Study of 1% Metformin Gel Applied Locally to Improve Dental Implant Stability and Bone Density

What this Trial Is About

Researchers are evaluating the local application of 1% metformin gel to improve implant stability and peri-implant bone density in patients needing dental implants. This randomized controlled clinical trial aims to determine whether metformin enhances the integration of implants with bone by comparing a test group receiving metformin gel to a control group receiving standard implant placement without additional treatment. In this study, participants will be randomly assigned to two groups. One group will receive the application of 1% metformin gel directly into the implant site immediately before implant placement. The other group will undergo the usual implant placement procedure without any local drug application. Implant stability will be measured using resonance frequency analysis at several time points, and bone density will be assessed with cone beam computed tomography CBCT imaging. Participants will be followed for at least three months after implant placement. Researchers will collect clinical and radiographic data to compare implant stability and bone density between groups over time. The primary outcome is bone density measured immediately after implant placement and at three months postoperatively. Secondary outcomes include implant stability assessed immediately, at six weeks, and at three months to monitor healing and implant success.

Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Study