Actively Recruiting
Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Clinical Study
Led by University of Baghdad · Updated on 2026-03-27
34
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the local application of 1% metformin gel to improve implant stability and peri-implant bone density in patients needing dental implants. This randomized controlled clinical trial aims to determine whether metformin enhances the integration of implants with bone by comparing a test group receiving metformin gel to a control group receiving standard implant placement without additional treatment. In this study, participants will be randomly assigned to two groups. One group will receive the application of 1% metformin gel directly into the implant site immediately before implant placement. The other group will undergo the usual implant placement procedure without any local drug application. Implant stability will be measured using resonance frequency analysis at several time points, and bone density will be assessed with cone beam computed tomography (CBCT) imaging. Participants will be followed for at least three months after implant placement. Researchers will collect clinical and radiographic data to compare implant stability and bone density between groups over time. The primary outcome is bone density measured immediately after implant placement and at three months postoperatively. Secondary outcomes include implant stability assessed immediately, at six weeks, and at three months to monitor healing and implant success.
CONDITIONS
Brief Title
Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients age at least 18 years old
- Partial edentulous teeth in bounded areas needing dental implant replacement
- Adequate bone volume for implant placement (at least 5 mm width and 10 mm height)
- Ability to tolerate conventional surgical and restorative procedures
- Willingness to comply with the study and provide consent
You will not qualify if you...
- Active infection or inflammation in the implant zone
- Presence of any uncontrolled systemic diseases
- History of chemotherapy or radiotherapy
- Prior bone grafting or soft tissue procedures before implant surgery
- Tooth extraction at the implant site less than 6 months before implant surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 months
Participants receive dental implant placement with either local application of 1% metformin gel at the implant site or standard implant placement without pharmacological application. Implant stability and peri-implant bone density are assessed during the healing period.
3 visits (immediately after implant placement, 6 weeks, and 3 months postoperatively)
Trial Site Locations
Total: 1 location
1
University of Baghdad -Collage of Dentistry
Baghdad, Baghdad Governorate, Iraq, 10001
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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