Actively Recruiting
The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery
Led by Montefiore Medical Center · Updated on 2025-12-16
150
Participants Needed
1
Research Sites
116 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Tranexamic acid (TXA) is a synthetic reversible competitive inhibitor to plasminogen lysine receptor, which prevents plasmin formation and stabilizes the fibrin matrix, thus reducing bleeding. While recent studies have demonstrated the antifibrinolytic benefits of TXA in obstetric and gynecologic conditions, traumatic hemorrhage, cardiac surgery, total knee arthroplasty, and more, there is a paucity of clinical data on TXA use in plastic surgery. The aim of this study is to evaluate the effect of local and systemic TXA on postoperative periocular ecchymosis/edema in orbital surgery.
CONDITIONS
Official Title
The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing orbital surgery (decompressions, fracture repairs, enucleations, eviscerations, etc.)
- Patients who are at least 18 years of age
- Patients that have the capacity to consent
You will not qualify if you...
- Any history of previous orbital surgery
- Any patient undergoing multiple simultaneous periocular surgical procedures
- Any patient with active infection
- History of stroke or seizure
- History of bleeding/clotting disorder
- Patients who do not comply with the required postoperative follow-up schedule
- Patients who are allergic to tranexamic acid
- Patients who have taken anticoagulant/antiplatelet agents (including aspirin) within 7 days prior to surgery
- Patients who have periocular ecchymosis or edema prior to surgery
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Montefiore Medical Center
The Bronx, New York, United States, 10467
Actively Recruiting
Research Team
A
Anne Barmettler
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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