Actively Recruiting
The Effect of Long-term Daily Stimulation of the Brain With Pulsed Electromagnetic Fields on Parkinsons Disease
Led by University of Southern Denmark · Updated on 2026-04-29
90
Participants Needed
2
Research Sites
97 weeks
Total Duration
On this page
Sponsors
U
University of Southern Denmark
Lead Sponsor
O
Odense University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn to what extent daily stimulation of the brain with transcranial pulsed electromagnetic fields (T-PEMF) works to treat persons with Parkinson's Disease. The main questions it aims to answer are: * How does 6 months of daily treatment (30 minutes/day) with T-PEMF affects neuro-mechanical and molecular biological factors compared with placebo treatment in persons with Parkinson's disease? * How does 12 months of daily treatment (30 minutes/day) with T-PEMF affects neuro-mechanical and molecular biological factors in persons with Parkinson's disease an does 12 months of T-PEMF alters the need for medication intake? The neuro-mechanical outcomes are compared with the "natural" progression of the disease as well as with a healthy reference group. Furthermore, it will be examined whether 12 months of T-PEMF treatment alters the need for medication intake. Participants in the intervention group will: * receive one 30 min treatment session daily for 12 months * receive either T-PEMF or sham treatment for the first 6 months * receive active T-PEMF treatment the last 6 months * visit for tests before treatment initiation, after 6 months of treatment and after 12 months of treatment.
CONDITIONS
Official Title
The Effect of Long-term Daily Stimulation of the Brain With Pulsed Electromagnetic Fields on Parkinsons Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with idiopathic Parkinson's disease
- Able to understand, accept, and complete planned procedures
- Parkinson's symptoms correspond to Hoehn & Yahr stage 1 or 2 in the medicated state
- Mini Mental-State Examination score greater than 22
- Able to understand, accept, and complete planned procedures (Healthy Reference Group)
You will not qualify if you...
- Cancer in the brain, neck, or head area
- Presence of active medical implants
- Epilepsy
- Alcoholism
- Substance abuse
- Open wound on the scalp
- Severe psychopathological disorders
- Pregnancy
- Changes in anti-Parkinson medication within 6 weeks before starting T-PEMF treatment
- Anticoagulant treatment with Marevan, Marcoumar, Pradaxa, Eliquis, Xarelto, Lixiana, Novostan, Fragmin, or Innohep
- Neurological diseases other than Parkinson's disease
- Previous stroke
- Reduced motor function caused by conditions other than Parkinson's disease
- Neurological disease (Healthy Reference Group)
- Reduced motor function caused by condition (Healthy Reference Group)
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Odense University Hospital
Odense, Denmark, 5000
Actively Recruiting
2
University of Southern Denmark
Odense, Denmark, 5230
Actively Recruiting
Research Team
A
Anne Sofie Bøgh Malling, Ph.d.
CONTACT
B
Bente Rona Jensen, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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