Actively Recruiting
The Effect of Losartan on Cephalexin
Led by Aleksi Tornio · Updated on 2026-03-25
12
Participants Needed
1
Research Sites
9 weeks
Total Duration
On this page
Sponsors
A
Aleksi Tornio
Lead Sponsor
T
Turku University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the effects of the blood pressure-lowering drug losartan on the blood levels and urinary excretion of the antibiotic cephalexin during simultaneous and staggered ingestion in healthy volunteers. The main questions it aims to answer are: 1. Does losartan affect cephalexin levels and excretion when ingested at the same time? 2. Does a three-hour interval between ingestion of losartan and cephalexin eliminate a possible effect? Researchers will compare the effects of losartan ingested at the same time, losartan ingested three hours prior, and no losartan ingested on oral cephalexin in each participant to see whether an interaction exists and could be avoided. Participants will visit the research laboratory on three days during which they will ingest single doses of losartan at the same time with, three hours prior to, and not at all prior to ingesting single doses of cephalexin.
CONDITIONS
Official Title
The Effect of Losartan on Cephalexin
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- Age between 18 and 40 years
- Good health
- Systolic blood pressure of at least 115 mmHg
- Acceptable screening laboratory results, with Pt-GFReEPI at or above reference limit and P-K at or below higher reference limit
- For females, a negative pregnancy test before the study and use of a highly effective contraceptive method
You will not qualify if you...
- Unable to provide written informed consent in Finnish
- Remarkable illness
- Confirmed or suspected allergy to cephalexin, amoxicillin, benzylpenicillin, phenoxymethylpenicillin, piperacillin, cefaclor, or cefamandole
- Confirmed or suspected severe delayed allergic reaction to any beta-lactam antibiotic
- Underweight (BMI less than 18.5 kg/m2)
- Obesity (BMI greater than 30 kg/m2)
- Smoking
- Regular medication use, including hormonal contraception
- Current or planned pregnancy, and breastfeeding
- Less than three months since participating in a prior clinical trial
- Less than three months since donating blood
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Unit of Clinical Pharmacology, Turku University Hospital
Turku, Southwest Finland, Finland, FI-20520
Actively Recruiting
Research Team
A
Aleksi Tornio, M.D., Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
6
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here