Actively Recruiting
Effect of Low Valine Diet on Body Weight and Metabolic Parameters
Led by Shanghai Zhongshan Hospital · Updated on 2025-03-19
48
Participants Needed
1
Research Sites
62 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aimed to explore the effects of ordinary meal replacements and low-valine meal replacements on the weight and risk of related metabolic diseases in overweight/obese patients through a randomized double-blind controlled clinical trial.
CONDITIONS
Official Title
Effect of Low Valine Diet on Body Weight and Metabolic Parameters
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, 16 years old 64 age 64 80 years old
- Body mass index (BMI) of 24 kg/m2 or higher
You will not qualify if you...
- Excessive alcohol intake: men over 140g/week, women over 70g/week in past 6 months
- Liver diseases from other causes such as alcoholic liver disease, viral hepatitis, drug-induced liver injury, immune hepatitis, cirrhosis, or liver cancer
- Other diseases affecting glucose and lipid metabolism like hyperthyroidism, hypothyroidism, or Cushing's syndrome
- Poorly controlled diabetes with HbA1c >9.5% in past 3 months or use of weight-affecting hypoglycemic drugs
- Chronic kidney disease or severe renal impairment with serum creatinine >2.0 mg/dL
- Serum ALT levels greater than three times the upper limit of normal
- Serious health conditions with life expectancy less than 3 years
- Planning pregnancy in the near future
- Unable to participate in follow-up due to other conditions
- Continuous use of weight-affecting drugs for more than 2 weeks in past year
- Participation in other clinical trials within past 4 weeks
- History of gastric volume reduction or digestive tract surgery
- Diagnosis of any tumor disease
- Participation in strenuous exercise or planned diet changes
- Unable to sign informed consent form
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200031
Actively Recruiting
Research Team
M
Mingfeng Xia
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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