Actively Recruiting
Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring
Led by Loma Linda University · Updated on 2026-04-24
50
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to assess the functional integrity of the neural pathways. The effect of Magnesium sulfate on IONM has not been studied. This is a prospective, double blind, randomized placebo controlled trial to study the effect of Magnesium sulfate bolus on the amplitude and latency of somatosensory(SSEPs) and motor evoked potentials(MEPs) in patients undergoing surgery requiring IONM.
CONDITIONS
Official Title
Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 80 years
- American Society of Anesthesiologists physical status I or II
- Scheduled for elective spine or cranial surgery requiring intraoperative neuromonitoring including SSEPs and MEPs
You will not qualify if you...
- Magnesium use within the last 2 days (oral or intravenous)
- Known electrolyte imbalances (Sodium <135 or >145 mmol/L, Potassium <3.5 or >5.0 mmol/L, Magnesium >1.2 mmol/L)
- Severe cardiac or conduction disorders
- Severe pulmonary disease
- Significant neuromuscular disorders or preexisting motor/sensory deficits except mild focal neuropathy or cervical radiculopathy/myelopathy
- Severe renal disease (serum creatinine >2 mg/dl)
- Pregnant or breastfeeding
- Unable to obtain adequate baseline SSEPs and MEPs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Loma linda University Medical Center
Loma Linda, California, United States, 92354
Actively Recruiting
Research Team
R
Rashmi Vandse, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here