Actively Recruiting
Effect of Magnesium Sulphate Pretreatment on the Onset and Duration of Neuromuscular Block of Rocuronium Versus Cis-Atracurium in Children Undergoing Abdominal Surgery
Led by Assiut University · Updated on 2025-01-20
58
Participants Needed
2
Research Sites
127 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effect of magnesium sulphate pretreatment on the start and length of intense and deep muscle relaxation caused by two drugs, rocuronium and Cis-Atracurium, in children aged 2 to 12 undergoing planned open abdominal surgeries. The study focuses on how magnesium sulphate influences the period during which there is no response to nerve stimulation, aiming to better understand its role in muscle relaxation during surgery. The study involves pretreating patients with a magnesium sulphate infusion at a dose of 30 mg per kg, given 20 minutes before anesthesia begins. The muscle relaxants rocuronium and Cis-Atracurium are then administered, with Cis-Atracurium given as an initial intravenous bolus followed by maintenance doses at fixed intervals. The trial compares these treatments to evaluate their effects on muscle relaxation timing and depth. Participants will be monitored during surgery, including using nerve stimulation to measure responses. The main outcome measured is the time during which there is no response to nerve stimulation. The study includes children scheduled for elective laparoscopic surgeries, with evaluations including anesthesia monitoring and safety assessments. Researchers will track the onset and duration of muscle relaxation and any related effects throughout the surgical procedure.
CONDITIONS
Official Title
Effect of Magnesium Sulphate Pretreatment in Pediatric Abdominal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 2 and 12 years old
- Any gender
- Scheduled for elective laparoscopic abdominal surgery
- American Society of Anesthesiologist physical status 1 or 2
You will not qualify if you...
- Outside the age range of 2 to 12 years
- Taking medications that affect muscle activity
- Allergy to the study medications
- Neuromuscular diseases
- Kidney or liver impairment
- Abnormal magnesium levels (high or low)
- Parental refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Pediatric hospital, faculty of medicine, Assiut university
Asyut, Assiut Governorate, Egypt, 715715
Actively Recruiting
2
Pediatric hospital
Asyut, Assiut Governorate, Egypt, 715715
Actively Recruiting
Research Team
H
Hala S Abdel-Ghaffar, MD
H
Heba S Hassan, Master
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here