Actively Recruiting
Effect of Mannitol on Propofol Level
Led by Cukurova University · Updated on 2025-09-02
40
Participants Needed
1
Research Sites
32 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Group 1 will include 20 patients aged 18 years and over, American Society of Anesthesiologist (ASA) II-III class, who will undergo supratentorial tumor surgery, and Group 2 will include 20 patients who will undergo pituitary surgery without mannitol. Total intravenous anesthesia (TIVA) will be adjusted to propofol 4 µg/dl and remifentanil 2-4 µg/dl with target-controlled infusion pumps. In the mannitol group, 2.5 ml/kg (0.5 g/kg) will be given to all patients 20 minutes after induction and the mannitol infusion will be adjusted to be 10 minutes.In Group 2, mannitol will not be used and 2.5 ml/kg isotonic will be administered in 10 minutes. Both blood and urine samples will take for measurement to propofol levels.
CONDITIONS
Official Title
Effect of Mannitol on Propofol Level
Who Can Participate
Eligibility Criteria
You may qualify if you...
- American Society of Anesthesiologist (ASA) II participants
- Undergoing supratentorial tumor surgery
- Eligible for mannitol use
- Eligible for Total intravenous anesthesia (TIVA)
You will not qualify if you...
- American Society of Anesthesiologist (ASA) III and above
- Chronic kidney failure
- Sepsis
- Multiorgan failure
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Çukurova University
Çukurova, Adana, Turkey (Türkiye)
Actively Recruiting
Research Team
E
Ebru Biricik
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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