Actively Recruiting
Effect of Mavacamten Treatment on Coronary Flow Reserve in oHCM
Led by Michael Ayers · Updated on 2024-11-06
20
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
Sponsors
M
Michael Ayers
Lead Sponsor
B
Bristol-Myers Squibb
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to measure the effect of mavacamten treatment on blood flow in the heart muscle (myocardium) in patients with obstructive hypertrophic cardiomyopathy. The main question it aims to answer is: • Does mavacamten treatment improve blood flow in the heart muscle? Participants will take mavacamten at the direction of their treating physician. Participants will complete 2 myocardial Positron Emission Tomography and Computed Tomography (PET-CT) scans. The first scan will be completed before participants start taking mavacamten. The scan will be repeated after 12 months of mavacamten treatment.
CONDITIONS
Official Title
Effect of Mavacamten Treatment on Coronary Flow Reserve in oHCM
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to provide written informed consent
- Willing and able to follow scheduled visits and study procedures
- Male or female aged 18 to 85 years
- Diagnosed with obstructive hypertrophic cardiomyopathy with left ventricular wall thickness ≥15 mm, or ≥13 mm if family history or genotype positive
- Prescribed mavacamten according to US Prescribing Information
- Able and intending to follow oral mavacamten therapy as directed
- For females of childbearing potential: negative pregnancy test at screening and after 12 months
You will not qualify if you...
- Pregnant or breastfeeding
- Known allergy to mavacamten or regadenoson components
- Previous treatment with mavacamten or aficamten
- Over weight limit for imaging equipment
- Left ventricular systolic dysfunction or lung disease that may affect PET/CT image quality
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Virginia
Charlottesville, Virginia, United States, 22908
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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