Actively Recruiting
The Effect of the Menstrual Cycle on Immune Cell Activity and Recovery After Resistance Exercise
Led by University of Central Florida · Updated on 2025-05-22
40
Participants Needed
1
Research Sites
36 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn how the menstrual cycle affects immune cell activation, recruitment, and recovery responses after resistance exercise in healthy, resistance-trained women aged 18-40. The main questions it aims to answer are: Does the menstrual cycle influence neutrophil recruitment and adhesion after resistance exercise? Does the menstrual cycle affect markers of muscle damage and functional recovery? Researchers will compare three menstrual phases (early follicular, late follicular, and mid-luteal) to see if immune responses and recovery outcomes differ across these phases. Participants will: Complete resistance exercise protocols across three different menstrual cycle phases. Provide blood samples to assess immune cell activation and muscle damage markers. Track sleep, mood, and recovery with questionnaires and wear an accelerometer.
CONDITIONS
Official Title
The Effect of the Menstrual Cycle on Immune Cell Activity and Recovery After Resistance Exercise
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women between the ages of 18 and 40
- Must weigh at least 110 pounds
- Healthy based on medical history, physical activity readiness, and menstrual cycle questionnaires
- Actively resistance training for at least 6 months with at least 3 sessions per week including one lower body session
- Pre-menopausal with regular menstrual cycles and clear start of menses
- Not pregnant or planning pregnancy during the study
- No hormonal birth control or intrauterine device use in past 3 months
- Able to recall approximate start dates of last 6 menstrual cycles
- Willing to follow study instructions including avoiding exercise, alcohol, and caffeine before testing
- No previous or current lower body injuries limiting performance
- Not regularly taking medications that interfere with the study
- High likelihood of successful blood draws as determined by certified phlebotomist
You will not qualify if you...
- Do not give consent to participate
- Unfit to participate based on medical or activity history
- Taking prescription or over-the-counter medications that affect study results
- Have a chronic illness requiring medical care
- Not resistance-trained as required
- Pregnant or planning pregnancy during the study
- Irregular periods or diagnosed amenorrhoeic
- Taking performance-enhancing drugs
- Using hormonal birth control or intrauterine devices currently or in past 3 months
- Unlikely to have successful blood draws as determined by certified phlebotomist
- Weigh less than 110 pounds
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Trial Site Locations
Total: 1 location
1
University of Central Florida
Orlando, Florida, United States, 32816
Actively Recruiting
Research Team
J
Jessica M Moon
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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