Actively Recruiting
Effect of Menstrual Phase on the Anesthetic Efficacy
Led by Jamia Millia Islamia · Updated on 2025-12-29
150
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational prospective clinical study is to learn whether the menstrual phase influences the anesthetic efficacy of inferior alveolar nerve block (IANB) in female patients aged 20-40 years with symptomatic irreversible pulpitis in mandibular molars. The main questions it aims to answer are: Does the success rate of IANB vary across different phases of the menstrual cycle? Are certain menstrual phases associated with a higher likelihood of anesthetic failure during endodontic access preparation? Researchers will compare five menstrual phase groups (menstrual, follicular, ovulatory, luteal, and premenstrual) to see if hormonal fluctuations affect anesthetic success. Participants will: Receive a standardized inferior alveolar nerve block using 2% lidocaine with 1:80,000 epinephrine Undergo cold testing and access cavity preparation to assess anesthetic success Have intraoperative pain recorded using the Heft-Parker Visual Analog Scale (HPVAS), with menstrual phase information recorded confidentially and blinded to the treating clinician
CONDITIONS
Official Title
Effect of Menstrual Phase on the Anesthetic Efficacy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 20 to 40 years
- Regular menstrual cycles of 28 ± 3 days
- Diagnosed with symptomatic irreversible pulpitis in mandibular molars
- Planned to undergo root canal therapy
- Willing to provide informed consent
You will not qualify if you...
- Use of oral contraceptives or hormonal therapy
- Irregular menstrual cycles
- Pregnancy or lactation
- Systemic diseases affecting pain perception (e.g., diabetes, neuropathies)
- Use of analgesics or sedatives within the last 24 hours
- Allergy to local anesthetics
AI-Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Dentistry, JMI
New Delhi, Delhi(दिल्ली), India, 110025
Actively Recruiting
Research Team
V
Vivek Aggarwal, MDS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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