Actively Recruiting
Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)
Led by University Of Nigeria Teaching Hospital · Updated on 2025-12-22
220
Participants Needed
2
Research Sites
114 weeks
Total Duration
On this page
Sponsors
U
University Of Nigeria Teaching Hospital
Lead Sponsor
C
Cures Within Reach
Collaborating Sponsor
AI-Summary
What this Trial Is About
Obesity is a chronic disease of global public health concern, contributing to cardiovascular disease, type 2 diabetes and certain cancers. Currently approved anti-obesity drugs and surgery are expensive and not readily available in Nigeria. Metformin, approved for type 2 diabetes, has been shown to promote weight loss among obese patients in high income countries. However, metformin's effects have not yet been demonstrated in Black African populations, which may have different genetic and environmental predispositions to obesity and to the effect of metformin. This blinded, placebo-controlled, randomized trial is determining the effect of metformin on weight loss, cardiovascular disease risk and insulin resistance in Black Nigerians.
CONDITIONS
Official Title
Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Obesity defined as body mass index of 30 kg/m2 or higher
- Fasting plasma glucose less than 7.0 mmol/L
- No medical treatment for weight control in the previous 12 months
- Not currently participating in any clinical trial
You will not qualify if you...
- Obesity defined as body mass index of 30 kg/m2 or higher
- Fasting plasma glucose less than 7.0 mmol/L
- No medical treatment for weight control in the previous 12 months
- Not currently participating in any clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Pathology Facility
Enugu, Enugu State, Nigeria
Actively Recruiting
2
University of Nigeria Teaching Hospital
Enugu, Enugu State, Nigeria
Actively Recruiting
Research Team
C
Chiamaka C Onu, BSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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