Actively Recruiting
Effect of Magnesium Sulphate Pretreatment on Cis-Atracurium Induced Neuromuscular Block and Recovery Characteristics: A Randomized Controlled Trial
Led by Assiut University · Updated on 2024-07-01
100
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effect of magnesium sulphate on muscle relaxation, specifically its impact on the onset and duration of neuromuscular block caused by cis-atracurium, as well as the time when there is no response to nerve stimulation. This study focuses on patients scheduled for elective otorhinolaryngological surgery and evaluates magnesium sulphate as an addition to anesthesia care to understand how it influences muscle relaxation during surgery. The study includes two groups: one receiving an infusion of magnesium sulphate (60 mg per kg, total 100 ml over 10 minutes) before anesthesia induction, and a comparator group receiving a saline infusion with the same volume and timing. Both infusions are administered intravenously 10 minutes before anesthesia begins, allowing comparison of magnesium sulphate's effect on neuromuscular blocking and recovery times. Participants will be monitored during surgery with assessments focusing on the duration of no response to nerve stimulation and the length of intense and deep neuromuscular block periods. The study uses randomized assignment and quadruple masking to ensure unbiased results. Outcomes are measured intraoperatively, and safety and recovery characteristics are observed. The trial spans a participation age range of 18 to 60 years and includes follow-up during the surgical procedure.
CONDITIONS
Brief Title
Effect of MgSO4 Pretreatment on Muscle Relaxation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age group 18-60 years old
- Both genders
- Patients scheduled to undergo elective otorhinolaryngological surgery
- Body mass index (BMI) between 18.5 and 24.9 Kg/m2
- American Society of Anesthesiologist physical status classification of 1 or 2
You will not qualify if you...
- Patients younger than 18 years or older than 60 years
- Use of medications that interfere with muscle activity
- Allergy to medications used in this study
- Pregnancy or suspected pregnancy
- Neuromuscular diseases
- Renal or hepatic impairment
- Hypermagnesemia (greater than 2.5 mmol) or hypomagnesemia (less than 1.7 mmol)
- Patients refusing to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day (day of surgery)
Participants receive an infusion of magnesium sulphate or saline 10 minutes before induction of anesthesia during their elective surgery.
1 treatment visit (in-person)
Duration - During surgery
Participants are monitored intraoperatively for neuromuscular block duration and recovery characteristics.
Assessments during surgery
Trial Site Locations
Total: 1 location
1
Assiut university main hospital, ENT operative theatre
Asyut, Asyut Governorate, Egypt, 71515
Actively Recruiting
Research Team
H
Hala S Abdel-Ghaffar, MD
A
Abu El Hassan A Rezk, MBB Ch
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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