Efficacy of Supplementation With Micronized Creatine Monohydrate in the Recovery of Muscle Mass, Muscle Strength and Functional Capacity in Older Adults Operated on for Total Knee Arthroplasty: Randomized Clinical Trial

What this Trial Is About

Researchers are evaluating the effects of micronized creatine monohydrate supplementation on muscle mass, strength, sarcopenia, frailty, functional capacity, and physical performance in older adults who have undergone total knee arthroplasty. This randomized, double-blind, placebo-controlled trial aims to assess the efficacy and safety of creatine supplementation alongside a usual rehabilitation program. The study is led by Consorci Sanitari del Maresme and focuses on adults aged 65 and older. Participants will be randomly assigned to one of two groups: an intervention group receiving creatine monohydrate and a control group receiving a placebo. Both groups will start supplementation at hospital discharge with a loading dose of 20g per day for 1 week, divided into four intakes to aid digestion. This will be followed by a maintenance dose of 5g per day for 11 weeks, taken with food to improve absorption. Both groups will follow the same rehabilitation program. During the study, researchers will assess muscle mass, muscle strength, sarcopenia prevalence, functional capacity, physical performance, aerobic capacity, walking speed, and adverse health events at baseline, 3 months, and 6 months follow-up. They will also monitor frailty status and arthroscopy complications. Participants will be involved in regular evaluations over the 6-month period to track changes and safety outcomes related to the supplementation.

Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty