Actively Recruiting
Effect of Misoprostol on Fluid Deficit Volume in Hysteroscopic Myomectomy
Led by Northwestern University · Updated on 2026-04-13
40
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this double blinded randomized control trial is to evaluate the impact of misoprostol on fluid deficit during hysteroscopic myomectomies. The main questions it aims to answer are: Is there is difference in fluid deficit in patients who receive misoprostol vs placebo pre operatively for hysteroscopic myomectomies? Participants will be randomized to received 800 mcg of either rectal misoprostol prior to their hysteroscopic myomectomy or 4 tablets of placebo (ZEEBO) prior to their hysteroscopic myomectomy.
CONDITIONS
Official Title
Effect of Misoprostol on Fluid Deficit Volume in Hysteroscopic Myomectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled for hysteroscopic myomectomy for uterine fibroids confirmed by pelvic ultrasound or MRI within the last 12 months
- Age 18 to 50 years
- Uterine fibroids sized between 1 and 3 cm
- Planned myomectomy using Myosure or resectoscope devices
- Willing to receive rectal misoprostol or placebo before the procedure
- Able to understand and sign informed consent
- Acceptable medical and surgical history
- May have been treated previously with Depo-Lupron, Depo-Provera, or oral contraceptive pills
- May have had prior Cesarean delivery
You will not qualify if you...
- Pregnancy; negative urine pregnancy test required before surgery
- Post-menopausal women
- History of gynecologic cancer
- Allergic reactions to misoprostol or similar compounds
- Uncontrolled illnesses such as active infection, symptomatic heart failure, unstable angina, cardiac arrhythmia, or psychiatric/social issues limiting study compliance
- Active inflammatory bowel disease involving the rectum or other anorectal conditions interfering with safe rectal medication use
AI-Screening
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Trial Site Locations
Total: 1 location
1
Northwestern
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
H
Hannah Pope, MD
CONTACT
J
Juan Avitia, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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