Actively Recruiting
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia
Led by University of Pittsburgh · Updated on 2025-06-19
15
Participants Needed
5
Research Sites
382 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease. The goal of this research is to study if MitoQ, a molecule that works as an antioxidant by removing potentially damaging agents in a living organism, improves platelet function in patients with sickle cell disease (SCD).
CONDITIONS
Official Title
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be African American
- Have sickle cell anemia (for subjects)
- Be a healthy African American volunteer (for control group)
- Be 18 years old or older
You will not qualify if you...
- Currently pregnant
- Have known hypertension
- Are undergoing hemodialysis
- Have active obstructive sleep apnea requiring treatment
- Use anti-platelet medication or have had a blood transfusion within 4 weeks prior to enrollment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 5 locations
1
Magee Women's Hospital
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
2
UPMC Montefiore
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
3
UPMC Presbyterian
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
4
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
5
Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
Research Team
M
Mikhil N Bamne, PhD
CONTACT
J
Jude Jonassaint, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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