Comparing Mobilization With Movement to Sham Treatment for Reducing Inflammation and Pain in Adults with Knee Osteoarthritis

What this Trial Is About

Researchers are investigating whether a hands-on therapy called Mobilization with Movement MWM can reduce pain and inflammation in adults with moderate to severe knee osteoarthritis OA. This study compares MWM to a sham treatment that looks like mobilization but does not include the specific therapeutic movements. Both groups also receive standard care, including an exercise program and education about managing knee OA. Participants will be randomly assigned to either the MWM group or the sham group. Each group receives treatment twice a week for four weeks. The MWM involves continuous gliding movements applied to the tibia during active knee flexion and extension, while the sham treatment simulates MWM by gently rotating the skin without affecting the joint. Both groups will follow a standard exercise program designed to strengthen the knee muscles. During the study, participants will have blood tests to measure inflammation markers such as C-Reactive Protein and Erythrocyte Sedimentation Rate at the start and after four weeks. Pain intensity and knee function will also be assessed at these times. The study aims to see if MWM leads to lower inflammation and less pain compared to the sham treatment. The total participation lasts for the four-week intervention period.

The Effect of Mobilization on Inflammatory Biomarkers in Patients With Knee Osteoarthritis.