Actively Recruiting
The Effect of Mobilization on Inflammatory Biomarkers in Patients With Knee Osteoarthritis.
Led by University of Jazan · Updated on 2025-12-09
40
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is designed to investigate whether a hands-on therapy called Mobilization with Movement (MWM) can reduce pain and inflammation in individuals with knee osteoarthritis (OA). The investigators will compare MWM to a sham treatment that resembles mobilization but does not involve the specific therapeutic movements. Both groups will also receive standard care, including exercise and education about managing knee OA. A total of 40 adults (aged 18 years and older) with moderate to severe knee OA will be enrolled. Participants will be randomly assigned to either the MWM group or the sham group. Each intervention will be delivered twice per week over a four-week period. Outcomes will include measures of inflammation obtained from blood samples, self-reported pain levels, and assessments of knee function before and after the intervention period. It is hypothesized that individuals allocated to the MWM group will demonstrate reduced inflammation and pain compared with those in the sham group. The findings of this study may help clarify the potential role of MWM as a treatment option for knee OA.
CONDITIONS
Official Title
The Effect of Mobilization on Inflammatory Biomarkers in Patients With Knee Osteoarthritis.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of unilateral or bilateral knee osteoarthritis (OA) according to the criteria of the American College of Rheumatology
- Age 18 years or older
- Kellgren-Lawrence grade 2 or 3 knee OA
- Pain intensity greater than 3 on a visual analogue scale (VAS)
- Body mass index (BMI) between 18.5 and 30 kg/m²
You will not qualify if you...
- Knee or lower limb surgery within the last six months
- Significant joint disorders such as rheumatoid arthritis, gout, or other inflammatory arthritis
- Recent significant acute infections
- Contraindications to mobilization with movement
- Current or recent use of systemic glucocorticoids, intra-articular glucocorticoid injections, or intra-articular hyaluronic acid injections
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Jazan University Hospital
Jizan, Jazan Region, Saudi Arabia, 82722
Actively Recruiting
Research Team
A
Abdulraouf Ayoub, PT
CONTACT
M
Mohammed Moslem, PT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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