Actively Recruiting
Effect of Montelukast on Inflammatory Markers and Cardiac Injury in Patients With Acute Myocardial Infarction
Led by October 6 University · Updated on 2026-05-08
80
Participants Needed
1
Research Sites
75 weeks
Total Duration
On this page
Sponsors
O
October 6 University
Lead Sponsor
M
Mansoura University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a randomized controlled clinical trial designed to evaluate the therapeutic effects of Montelukast in patients diagnosed with Acute Myocardial Infarction (AMI). The study aims to investigate whether the administration of Montelukast influences inflammatory markers and the extent of cardiac injury following a heart attack.Participants will be randomly assigned to receive either the active medication or a placebo to provide high-quality evidence regarding the drug's potential cardioprotective and anti-inflammatory properties. The trial is conducted through the Faculty of Pharmacy and Faculty of Medicine at Mansoura University
CONDITIONS
Official Title
Effect of Montelukast on Inflammatory Markers and Cardiac Injury in Patients With Acute Myocardial Infarction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 30 and 75 years
- Diagnosed with STEMI within 6 hours of symptom onset
- Undergoing PCI or thrombolysis treatment
- Eligible for standard acute coronary syndrome therapy
- Signed informed consent to participate
You will not qualify if you...
- Chronic use of anti-inflammatory drugs
- Severe liver or kidney impairment
- Allergy or hypersensitivity to Montelukast
- Presence of autoimmune or inflammatory diseases
- Cardiogenic shock, severe heart failure, or structural heart complications such as papillary muscle rupture
- History of cardiopulmonary resuscitation
- Severe and uncontrolled high blood pressure
- Previous myocardial infarction
- Active bleeding or visceral hemorrhage
- Current malignant tumors, lymphomas, leukemias, or other serious diseases
- Gastrointestinal surgery in the past 4 weeks affecting drug absorption
- Family history of psychiatric disorders
- Pregnancy or breastfeeding
- Participation in another clinical trial
AI-Screening
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Trial Site Locations
Total: 1 location
1
Mansoura Faculty of Medicine hospital
Al Mansurah, Egypt
Actively Recruiting
Research Team
A
Abdallah Alshammari, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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