Actively Recruiting
Effect of MOPs During Orthodontic Movement in Periodontitis Patients
Led by Universidad Complutense de Madrid · Updated on 2025-03-27
28
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Micro-osteoperforations (MOPs) cause cortical bone injuries and consequently increase the expression of inflammatory mediators, allowing for increased bone and periodontal ligament remodeling associated with orthodontic movement. It remains unclear the effect of orthodontic intrusion combined with MOPs application on teeth with reduced periodontium. The general objective will be to determine the efficacy of MOPs during orthodontic tooth movement (OTM) in terms of periodontal and orthodontic outcomes in stage IV periodontitis patients, case type 2 with pathological tooth migration (PTM), characterized the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabony component \<5mm)
CONDITIONS
Official Title
Effect of MOPs During Orthodontic Movement in Periodontitis Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients older than 18 years
- Systemically healthy
- Diagnosed with stage IV case-type 2 periodontitis
- At least one flared upper anterior tooth with an intrabony defect less than 5 mm
- In need of orthodontic therapy
You will not qualify if you...
- Having systemic diseases such as diabetes, obesity, or cardiovascular diseases
- Taking medications that affect inflammation like antibiotics, phenytoin, cyclosporin, anti-inflammatory drugs, corticosteroids, or calcium channel blockers
- Pregnant or breastfeeding women
- Unable to answer questions or attend follow-up visits
- Severe skeletal malocclusions requiring surgery
- Smoking more than 10 cigarettes per day
- Presence of probing depth 5 mm or greater with bleeding on probing after initial periodontal treatment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Odontology, University Complutense Madrid
Madrid, Madrid, Spain, 28040
Actively Recruiting
Research Team
C
Conchita Martin, Prof
CONTACT
E
Elena Figuero, Prof
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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