Actively Recruiting
The Effect of Morning vs Evening Aerobic Exercise Training on Cardiac Remodeling and Function Improvement in Patients After ST Elevation Myocardial Infarction
Led by RenJi Hospital · Updated on 2024-12-31
201
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cardiovascular disease is a leading cause of death worldwide, with over 30% of related deaths due to ST-segment Elevation Myocardial Infarction (STEMI). Aerobic exercise after STEMI has been shown to improve survival and heart function, but the best time of day for exercise to provide optimal heart benefits is not yet known. This study aims to evaluate whether morning or evening aerobic exercise can better improve heart remodeling and function in patients after STEMI. Participants will be randomly assigned to one of three groups: a morning aerobic exercise group exercising from 8:00 to 9:00 AM, an evening aerobic exercise group exercising from 4:00 to 5:00 PM, or a control group receiving standard care including medication and lifestyle advice. The exercise programs last 12 weeks with sessions three times a week, each including warm-up, aerobic, and relaxation exercises. Exercise intensity will be personalized based on initial testing and monitored using a fatigue scale. During the study, researchers will measure heart function through left ventricle ejection fraction at baseline, six weeks, and after 12 weeks of training or follow-up. Additional assessments include oxygen consumption, endothelial function, muscle and fat mass, cardiac structure, blood glucose and lipids, and heart-related biomarkers. Participants will be monitored for major cardiovascular events up to one year after rehabilitation, with ongoing follow-up to assess the lasting effects of exercise timing on heart health.
CONDITIONS
Brief Title
The Effect of Morning vs Evening Aerobic Exercise Training on Cardiac Remodeling and Function Improvement in Patients After ST Elevation Myocardial Infarction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 18 and 75-years-old
- Typical symptoms of acute myocardial infarction within 24 hours, with ST segment elevation of 61mm in two consecutive leads on electrocardiogram
- After receiving complete revascularization treatment
- Cardiac function grading I to II without any other serious complications
- Left ventricular ejection fraction >30%
- Compliant with the guidelines of the American College of Cardiology/American Heart Association for participating in cardiac rehabilitation standards
- Signed written informed consent.
You will not qualify if you...
- Patients with unstable angina
- Severe symptomatic congestive heart failure detectable myocardial ischemia
- Valvular disease requiring surgery
- Severe ventricular arrhythmias
- Severe concomitant life-threatening diseases such as cancer, and rheumatoid disease
- Osteoarticular diseases that may affect the exercise process
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants undergo a 12-week outpatient aerobic exercise training program three times a week, either in the morning or evening, including warm-up, aerobic, and relaxation exercises. Exercise intensity is personalized and gradually increased based on individual fitness assessments.
Three visits per week for 12 weeks (outpatient sessions)
Duration - 1 year
Participants are followed for one year after completing the exercise program to monitor major adverse cardiovascular events and overall cardiac health.
Regular follow-up visits over one year
Trial Site Locations
Total: 1 location
1
Renji Hospital
Shanghai, China
Actively Recruiting
Research Team
J
Jun PU, MD
Y
YiHong Du, Master
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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