Actively Recruiting
Effect of MTX Discontinuation on Shingrix Response in RA
Led by Konkuk University Medical Center · Updated on 2024-08-28
110
Participants Needed
1
Research Sites
70 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if methotrexate discontinuation affect on immunogeneity of shingrix in RA patients. The main questions it aims to answer are: Discontinuation of methotrexate after shingrix immunization increase efficacy of the vaccine in patients with RA ? Researchers will compare humoral and cell-mediated immunity against herpes zoster in RA patients who are vaccinated by shingrix, and compare these immunity between RA patients with MTX discontinuation and MTX continuation groups. Participants will: Vaccinated with shingrix twice. MTX continuation group will keep taking MTX after shingrix vaccination, whereas MTX discontinuation group will stop MTX for 2 weeks after shingrix vaccination. Visit the clinic at baseline (first shingrix vaccination), 2 months later for 2nd shingrix vaccination, then 3 \& 6 months later from baseline to achieve blood sample.
CONDITIONS
Official Title
Effect of MTX Discontinuation on Shingrix Response in RA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Fulfill 2010 ACR/EULAR classification criteria for rheumatoid arthritis
- Age over 19 years
- Current methotrexate user
- Agree to vaccination with Shingrix
You will not qualify if you...
- Have other forms of inflammatory arthritis or autoimmune-mediated diseases
- Have malignancy
- Have a current infection
- Are pregnant
AI-Screening
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Trial Site Locations
Total: 1 location
1
Konkuk University Medical Center
Seoul, South Korea
Actively Recruiting
Research Team
H
Hong Ki Min, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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