Detection and clinical significance of circulating tumour cells in patients with colorectal carcinoma.
P Ihnát, J Srovnal, J Hrubovčák...
https://pubmed.ncbi.nlm.nih.gov/38302423Actively Recruiting
Age: 18Years +
All Genders
ID07112937
The Effect of Multimodal Treatment of Rectal Cancer on Circulating Tumor Cells: A Prospective, Observational Study
Led by The Institute of Molecular and Translational Medicine, Czech Republic · Updated on 2025-08-08
150
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a prospective observational study focusing on patients with rectal cancer who are receiving multimodal treatment. The main goal is to track changes in circulating tumor cells (CTCs) in the blood during the treatment process. This study compares CTC levels in patients who receive neoadjuvant chemoradiotherapy with those who do not. The study involves collecting peripheral blood samples from each participant at five specified times: before starting neoadjuvant chemoradiotherapy, during the third week of chemoradiotherapy, before surgery, one week after surgery, and one month after surgery. These samples will be analyzed to measure the presence and amount of circulating tumor cells. Participants will undergo blood draws at these scheduled times to monitor CTC levels. The researchers aim to understand how CTC levels change throughout the treatment course. The total duration of participation depends on the timing of treatment and surgery, with careful monitoring at each time point to assess the primary outcome measure, which is the level of circulating tumor cells in peripheral blood.
CONDITIONS
Brief Title
The Effect of Multimodal Treatment of Rectal Cancer on Circulating Tumor Cells: A Prospective, Observational Study
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Diagnosed with rectal cancer
- Age 18 years or older
You will not qualify if you...
- Diagnosis of any other cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Neoadjuvant Chemoradiotherapy Monitoring
Duration - Duration of chemoradiotherapy course
Participants undergoing neoadjuvant chemoradiotherapy have circulating tumor cells measured at multiple points during treatment.
3 visits during chemoradiotherapy
Pre-Surgery Assessment
Duration - 1 week before surgery
Circulating tumor cells are measured before surgery.
1 visit (in-person)
Post-Surgery Follow-up
Duration - 1 month
Participants have circulating tumor cells measured one week and one month after surgery.
2 visits after surgery
Trial Site Locations
Total: 1 location
1
University Hospital Ostrava
Ostrava, Czechia
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Research Team
J
Josef Srovnal, Associate professor, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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