Actively Recruiting
The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness
Led by Wageningen University · Updated on 2026-04-22
30
Participants Needed
1
Research Sites
84 weeks
Total Duration
On this page
Sponsors
W
Wageningen University
Lead Sponsor
G
Gelderse Vallei Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to study how whole-body electrical stimulation combined with amino acid intake affects muscle health in ventilated ICU patients. The main questions to answer are: * Does electrostimulation improve the balance of muscle protein in ICU patients? * Does combining electrostimulation with amino acid help build muscle and prevent muscle loss? Researchers will compare three groups of patients: 1. Sham electrostimulation (no current applied) + the standard nutrition 2. Electrostimulation + the standard nutrition 3. Electrostimulation + a 20g amino acid bolus Participants will: * Receive either real or sham electrostimulation * Get their standard nutrition or a 20g amino acid bolus * Have marked amino acids given through an IV * Have blood samples taken to measure the amino acids and glucose in the blood * Undergo ultrasound of the upper arm to measure the blood flow
CONDITIONS
Official Title
The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Expected to need mechanical ventilation for at least 48 hours, as judged by a physician
- Expected to reach a Richmond Agitation-Sedation Scale (RASS) score of -4 or -5 (complete sedation), as judged by a physician
- Informed consent obtained from the next-of-kin
- Able to receive or currently receiving gastric tube feeding
- Have an arterial and a venous line already in place
You will not qualify if you...
- Spinal cord injury
- Previous surgery or local wounds that prevent whole-body NMES
- Conditions that prohibit NMES, such as open wounds
- Chronic neuromuscular disorders like Amyotrophic lateral sclerosis (ALS)
- Acute Kidney Injury stage II or III
- Currently undergoing continuous veno-venous hemofiltration (CVVH)
- Rhabdomyolysis
- Use of neuromuscular blocking agents
- In the caloric restriction phase of refeeding syndrome
- Currently in prone position
- Burn wounds
- Have an implantable cardioverter defibrillator (ICD) or pacemaker
- Pregnant
- Deemed unsuitable to participate by the treating intensivist
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Trial Site Locations
Total: 1 location
1
Hospital Gelderse Vallei
Ede, Netherlands
Actively Recruiting
Research Team
M
Marlou Dirks, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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