Actively Recruiting
The Effect of NAD Supplementation on Brain Vascular Health in Aging
Led by University of Oklahoma · Updated on 2026-04-01
214
Participants Needed
1
Research Sites
239 weeks
Total Duration
On this page
Sponsors
U
University of Oklahoma
Lead Sponsor
U
University of Pennsylvania
Collaborating Sponsor
AI-Summary
What this Trial Is About
Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.
CONDITIONS
Official Title
The Effect of NAD Supplementation on Brain Vascular Health in Aging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 to 85 years
- Adequate hearing and visual acuity to participate in the examinations
- Ability to read and write in English
- Competence to provide informed consent
- Mini-Mental State Exam score 24 or higher
You will not qualify if you...
- Vision or hearing impairment that would impair the ability to complete study assessments
- Active central nervous system disease including multiple sclerosis, uncontrolled seizures, active brain cancer
- Cerebrovascular accident other than transient ischemic attack within 60 days prior to Visit 0
- Major psychiatric disease including major depression not controlled with medications, alcohol or drug abuse
- Abnormal kidney function (creatinine >2mg/dL or estimated glomerular filtration rate <30 mL/min) by labs within 6 months prior to Visit 0
- Elevated liver enzymes (AST and/or ALT above twice the upper limit of normal) by labs within 6 months prior to Visit 0
- Treatment with other NAD enhancers within 4 weeks prior to randomization
- Any other medical condition that the investigator considers would make the participant inappropriate or too unstable to complete the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73117
Actively Recruiting
Research Team
A
Andriy Yabluchanskiy, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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