Comparing Nasal CPAP and NIPPV Effects on Diaphragm Activity in Very Low Birth Weight Preterm Infants

What this Trial Is About

Premature babies often have underdeveloped lungs and respiratory muscles, requiring breathing support to prevent lung collapse and assist breathing. This trial compares two types of breathing support for very low birth weight VLBW preterm infants traditional nasal Continuous Positive Airway Pressure CPAP and Non-Invasive Positive Pressure Ventilation NIPPV. The goal is to measure the electrical activity of the diaphragm Edi to better understand how these supports affect the babys breathing effort. Participants will receive three types of breathing support in varying sequences traditional CPAP, NIPPV, and high-pressure CPAP. Each support method is applied for 2 hours, totaling 6 hours of monitoring. A special feeding tube with sensors will measure the diaphragms electrical activity during each method, while routine monitoring of oxygen saturation, heart rate, and respiratory rate continues. Throughout the study, babies will be closely observed while the Edi signals are recorded. After completing the 6-hour protocol, babies will return to their originally prescribed breathing support. Researchers will analyze differences in diaphragm activity and other respiratory measures to compare the effects of the three support methods. The study is conducted in a neonatal intensive care unit and involves stable preterm infants born weighing less than 1500 grams.

Effect of Nasal CPAP Versus NIPPV On Diaphragm Electrical Activity (Edi) In VLBW Preterm Infants