Actively Recruiting
Effect of Nasal Spray Dexmedetomidine on Emergence Delirium Prevention in Total Hip Replacement
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2025-01-23
264
Participants Needed
1
Research Sites
19 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Emergence Delirium (ED) is a common postoperative complication refers to an acute brain dysfunction that occurs during the recovery from general anesthesia, which is mainly characterized by sudden attention and consciousness disorders. The occurrence of ED increases the risk of self-injury, wound dehiscence, accidental catheter dislocation, and postoperative delirium, and is also associated with postoperative cognitive deterioration and increased utilization of medical resources after discharge.
CONDITIONS
Official Title
Effect of Nasal Spray Dexmedetomidine on Emergence Delirium Prevention in Total Hip Replacement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 years or older
- Scheduled for total hip arthroplasty under general anesthesia
- Classified as ASA physical status II or III
- Provided informed consent or consent obtained from guardian
You will not qualify if you...
- Allergy or contraindication to dexmedetomidine
- Severe rhinitis or nasal deformity
- Severe bradycardia (heart rate less than 50 beats per minute) or grade 2 or higher atrioventricular block
- Permanent pacemaker implantation
- Severe heart failure or ejection fraction less than 30%
- History of myocardial infarction, unstable angina, severe arrhythmia, or cardiac insufficiency
- Emergency surgery
- Severe liver or kidney dysfunction (Child-Pugh class B or C, CKD stage 3 to 5)
- Preexisting mental illness, cognitive impairment, or communication difficulties preventing evaluation
- Presence of delirium before surgery
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
闗闗
Hangzhou, China
Actively Recruiting
Research Team
M
Min Yan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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