Actively Recruiting
Effect of Neoadjuvant Chemotherapy on MRI Accuracy Before Cystectomy
Led by Assiut University · Updated on 2025-10-02
76
Participants Needed
2
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if neoadjuvant chemotherapy (NAC) affects the accuracy of magnetic resonance imaging (MRI) in staging muscle-invasive bladder cancer (MIBC). This study will also assess how tissue changes induced by NAC impact MRI interpretation. The main questions it aims to answer are: Does NAC compromise the accuracy of MRI in staging MIBC? Does NAC-induced tissue change affect the reliability of MRI in tumor assessment? Researchers will compare MRI staging accuracy in MIBC patients who received NAC to those who went directly to surgery, to see if NAC impacts MRI's diagnostic performance. Participants will: Undergo MRI scanning before surgery Receive either NAC or go directly to surgery, depending on their group assignment Have their MRI results compared to histopathological outcomes after surgery
CONDITIONS
Official Title
Effect of Neoadjuvant Chemotherapy on MRI Accuracy Before Cystectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with cT2 urothelial carcinoma of the urinary bladder according to TNM classification
- Provided informed, written consent to participate and agree to all study requirements
You will not qualify if you...
- Received pelvic radiotherapy
- Had previous open or laparoscopic pelvic surgery
- Have contraindications to MRI
- Unfit for or refuse radical cystectomy
- Ineligible for cisplatin treatment
- Histopathology shows squamous differentiation
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Urology Department, Faculty of Medicine, Assiut University
Asyut, Asyut Governorate, Egypt, 71515
Not Yet Recruiting
2
Urology Department, Faculty of Medicine, Assiut University
Asyut, Asyut Governorate, Egypt, 71515
Actively Recruiting
Research Team
H
Hamza Elhashamy, MBBCh
CONTACT
A
Abdelrahman Abdelshafi, MBBCh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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