The impact of white matter lesions on seizure recurrence after first epileptic seizures in the elderly: a prospective study.
Jenny Weil, Louise Linka, Mariana Gurschi...
https://pubmed.ncbi.nlm.nih.gov/40394715Actively Recruiting
Led by University Hospital Marburg · Updated on 2025-02-20
1000
Participants Needed
1
Research Sites
17 weeks
Total Duration
Researchers are studying the effects of new diagnostic criteria for epilepsy introduced in 2014 by the International League Against Epilepsy. This study focuses on adults who have experienced their first epileptic seizure, examining how these updated criteria influence seizure frequency, medication adherence, quality of life, and cognitive performance over time. The study also explores potential changes in epilepsy incidence and severity due to improved early diagnosis and treatment methods, including enhanced imaging techniques. This observational study follows participants after their initial seizure, using questionnaires and neuropsychological tests to assess cognitive deficits and socio-economic impacts. It tracks outcomes such as employment status, salary, driving restrictions, and various cognitive tests over a ten-year period. The study aims to understand the health economic and neuropsychological consequences of early-stage epilepsy and the new diagnostic approach. Participants will undergo regular evaluations including neuropsychological testing and questionnaires to monitor cognitive abilities, quality of life, and social outcomes. The primary outcome is the rate of seizure recurrence over ten years, with secondary outcomes covering employment, salary, driving restrictions, and multiple cognitive assessments. The study is conducted at a single center and monitors participants' health and social factors longitudinally to capture the full impact of the new epilepsy criteria.
CONDITIONS
Effect of the New Definition of Epilepsies of the ILAE of 2014 on the Diagnosis After the First Seizure
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Initial assessment period
Participants undergo diagnostic assessments including imaging and EEG to classify the type of epilepsy based on the new 2014 diagnostic criteria.
1 to 2 visits depending on diagnostic needs
Duration - Up to 10 years
Participants are observed over a long-term period to record seizure recurrence, cognitive performance, quality of life, and socio-economic outcomes after the first seizure.
Periodic visits over 10 years for follow-up assessments
Total: 1 location
1
c/o Klinik für Neurologie
Marburg, Hesse, Germany, 35043
Actively Recruiting
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Jenny Weil, Louise Linka, Mariana Gurschi...
https://pubmed.ncbi.nlm.nih.gov/40394715