Actively Recruiting

Age: 18Years +
All Genders
ID06836687

Study of the New 2014 Epilepsy Definition's Effect on Diagnosis, Patient Satisfaction, Cognition, and Economic Outcomes After First Seizure

Led by University Hospital Marburg · Updated on 2025-02-20

1000

Participants Needed

1

Research Sites

17 weeks

Total Duration

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AI-Summary

What this Trial Is About

Researchers are studying the effects of new diagnostic criteria for epilepsy introduced in 2014 by the International League Against Epilepsy. This study focuses on adults who have experienced their first epileptic seizure, examining how these updated criteria influence seizure frequency, medication adherence, quality of life, and cognitive performance over time. The study also explores potential changes in epilepsy incidence and severity due to improved early diagnosis and treatment methods, including enhanced imaging techniques. This observational study follows participants after their initial seizure, using questionnaires and neuropsychological tests to assess cognitive deficits and socio-economic impacts. It tracks outcomes such as employment status, salary, driving restrictions, and various cognitive tests over a ten-year period. The study aims to understand the health economic and neuropsychological consequences of early-stage epilepsy and the new diagnostic approach. Participants will undergo regular evaluations including neuropsychological testing and questionnaires to monitor cognitive abilities, quality of life, and social outcomes. The primary outcome is the rate of seizure recurrence over ten years, with secondary outcomes covering employment, salary, driving restrictions, and multiple cognitive assessments. The study is conducted at a single center and monitors participants' health and social factors longitudinally to capture the full impact of the new epilepsy criteria.

CONDITIONS

Brief Title

Effect of the New Definition of Epilepsies of the ILAE of 2014 on the Diagnosis After the First Seizure

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Completion of the 18th year of life
  • First epileptic seizure
  • Ability to understand the patient information and to give written consent
  • Written consent for voluntary participation in the study
Not Eligible

You will not qualify if you...

  • Chronic drug or alcohol abuse in the last two years

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Initial assessment period

Participants undergo diagnostic assessments including imaging and EEG to classify the type of epilepsy based on the new 2014 diagnostic criteria.

1 to 2 visits depending on diagnostic needs

Long-term Monitoring

Duration - Up to 10 years

Participants are observed over a long-term period to record seizure recurrence, cognitive performance, quality of life, and socio-economic outcomes after the first seizure.

Periodic visits over 10 years for follow-up assessments

Trial Site Locations

Total: 1 location

1

c/o Klinik für Neurologie

Marburg, Hesse, Germany, 35043

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How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

The impact of white matter lesions on seizure recurrence after first epileptic seizures in the elderly: a prospective study.

Jenny Weil, Louise Linka, Mariana Gurschi...

https://pubmed.ncbi.nlm.nih.gov/40394715