Actively Recruiting
Effect of Nitrous Oxide on Aggression.
Led by Ohio State University · Updated on 2025-03-27
50
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
O
Ohio State University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this experimental medicine clinical trial is to test the hypothesis that nitrous oxide inhalation will result in a change in neurocircuit function in healthy controls and in individuals with impulsive aggressive tendencies. The main question aims to answer are: Does Nitrous Oxide normalize brain circuit function in impulsively aggressive individuals 24 hours after inhalation. Participants will undergo a 60 minute inhalation session with 50% Nitrous Oxide (or room air at another session) and then undergo an fMRI scan 24 hours later. Researchers will compare healthy controls and impulsively aggressive individuals to see if Nitrous Oxide can normalize the function of cortico-limbic circuits in the latter group.
CONDITIONS
Official Title
Effect of Nitrous Oxide on Aggression.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 21 and 55 years of age
- Physically healthy with no significant medical conditions
- Able to give informed consent
- For IED participants: meet current DSM-5 criteria for IED
- For IED participants: have LHA aggression scores greater than 12
- For IED participants: no history of psychosis, bipolar disorder, developmental disorder, intellectual disability, or current substance use disorder
- For healthy controls: no current or lifetime DSM-5 psychiatric disorder
- For healthy controls: LHA aggression scores less than 12
You will not qualify if you...
- PCL Screening Version Score greater than 13 (likely psychopathic)
- Current DSM-5 Major Depressive Episode
- History of bipolar disorder, schizophrenia, or organic mental syndrome
- Intellectual disability (IQ less than 70)
- History of nitrous oxide abuse or dependence
- Clinically significant medical condition
- Current moderate or severe alcohol or drug use disorder not in full remission
- Use of antipsychotic medication within the past two weeks
- Unwilling or unable to sign informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Ohio State University Wexner Medical Center
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
J
Jayla Copland, B.A.
CONTACT
J
Julian Roberts, R.N.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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