Functional electrical stimulation to enhance reactive balance among people with hemiparetic stroke.
Rudri Purohit, Gonzalo Varas-Diaz, Tanvi Bhatt
https://pubmed.ncbi.nlm.nih.gov/38214733/Actively Recruiting
Led by University of Illinois at Chicago · Updated on 2026-05-22
20
Participants Needed
1
Research Sites
13 weeks
Total Duration
Researchers are evaluating how neuromuscular electrical stimulation NMES, specifically functional electrical stimulation FES, affects reactive balance and walking in people who have had a stroke. The study focuses on individuals with chronic stroke who experience foot drop and muscle weakness, which lead to slower, less stable walking and increased risk of falls. The goal is to see if stimulating certain lower limb muscles can improve movement and balance following slips or trips. Participants will undergo two sessions the first includes screening, and the second involves testing with FES applied to various muscles on the weaker side of the body. During the study, participants will experience slip- and trip-like disturbances while walking on specialized equipment and in outdoor settings, with and without FES. The stimulation is controlled by software that times muscle activation to match walking phases and perturbations, using adjustable intensities and frequencies. Throughout the study, participants will perform standardized walking tests and experience controlled balance disturbances while researchers measure balance recovery and walking parameters. Data collected include fall occurrences, step timing, stability measures, and walking speed. The study also monitors safety factors like heart rate and oxygen levels. Participation involves two main sessions, and the research team will analyze how FES influences balance and gait in stroke survivors.
CONDITIONS
Effect of NMES on Balance and Fall Risk in Chronic Stroke
R
Rudri M Purohit, MS,PT
L
Lakshmi Kannan, MS,PT
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University of Illinois at Chicago
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Investigational NMES/FES + Perturbation Training | Standard Rehabilitation (with AFO or FES) |
|---|---|---|
| What it is | A therapeutic protocol combining neuromuscular or functional electrical stimulation with perturbation‑based balance and gait training using ActiveStep treadmill and Surefooted platform | Conventional balance and gait rehabilitation that may include ankle‑foot orthosis or functional electrical stimulation per current practice guidance |
| Primary use | To enhance reactive balance and reduce laboratory‑induced fall risk in people with chronic stroke | To maintain or improve balance and gait function using conventional rehabilitation tools like AFO or FES |
| Evidence status | Investigational; efficacy in reducing fall risk is currently being evaluated in this trial | FES and AFO have strong evidence supporting improved mobility and balance post‑stroke per recent clinical guidelines |
| Important limitations | Single‑group early‑phase design without comparator arm limits causal inference; results may not generalize to broader stroke populations | General recommendations; actual effectiveness varies by patient characteristics and training intensity |
| Patient impact | Not yet established; trial is assessing impact on fall risk reduction | Evidence supports functional improvements in gait and balance which may reduce fall risk in chronic stroke |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single session
Participants undergo neuromuscular electrical stimulation (NMES) or functional electrical stimulation (FES) during balance and gait training protocols involving reactive balance tasks and walking tests.
2 sessions including initial screening and experimental training
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Rudri Purohit, Gonzalo Varas-Diaz, Tanvi Bhatt
https://pubmed.ncbi.nlm.nih.gov/38214733/University of Illinois at Chicago
Lead Sponsor