Actively Recruiting

Phase Not Applicable
Age: 18Years - 90Years
All Genders
ID04957355

Effect of Neuromuscular Electrical Stimulation (NMES) on Reactive Balance, Gait and Fall-risk in Individuals With Stroke

Led by University of Illinois at Chicago · Updated on 2026-05-22

20

Participants Needed

1

Research Sites

13 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating how neuromuscular electrical stimulation (NMES), specifically functional electrical stimulation (FES), affects reactive balance and walking in people who have had a stroke. The study focuses on individuals with chronic stroke who experience foot drop and muscle weakness, which lead to slower, less stable walking and increased risk of falls. The goal is to see if stimulating certain lower limb muscles can improve movement and balance following slips or trips. Participants will undergo two sessions: the first includes screening, and the second involves testing with FES applied to various muscles on the weaker side of the body. During the study, participants will experience slip- and trip-like disturbances while walking on specialized equipment and in outdoor settings, with and without FES. The stimulation is controlled by software that times muscle activation to match walking phases and perturbations, using adjustable intensities and frequencies. Throughout the study, participants will perform standardized walking tests and experience controlled balance disturbances while researchers measure balance recovery and walking parameters. Data collected include fall occurrences, step timing, stability measures, and walking speed. The study also monitors safety factors like heart rate and oxygen levels. Participation involves two main sessions, and the research team will analyze how FES influences balance and gait in stroke survivors.

CONDITIONS

Brief Title

Effect of NMES on Balance and Fall Risk in Chronic Stroke

Who Can Participate

Age: 18Years - 90Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18 and 90 years
  • Presence of hemiparesis
  • Stroke occurred more than 6 months ago
  • Ability to walk independently with or without assistive device for at least 300 feet
  • Can understand and communicate in English
  • Cognitively and behaviorally able to follow study procedures (Montreal Cognitive Assessment score above 25)
Not Eligible

You will not qualify if you...

  • Heart rate above 85% of age-predicted maximum at rest
  • Resting systolic blood pressure over 165 mmHg or diastolic pressure over 110 mmHg
  • Oxygen saturation below 95% at rest
  • Body weight over 250 pounds
  • Any neurological condition other than stroke
  • Cardiopulmonary, musculoskeletal, or systemic diagnosis
  • Recent major surgery within 6 months or hospitalization within 3 months
  • History of deep vein thrombosis
  • Previous cancer diagnosis
  • Peripheral nerve injury or neuropathy causing motor disability in affected limb
  • Spasticity greater than 2 on Ashworth scale
  • Uncontrolled high blood pressure or angina
  • Skin conditions intolerant to electrical stimulation therapy
  • Uncontrolled seizure disorder
  • Botox treatment within past 5 months
  • History of epilepsy
  • Use of pacemaker
  • Non-English speaking individuals are excluded due to consent and instruction language requirements
  • Excluded or vulnerable populations as defined by study criteria are not eligible

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Implementation

Duration - Single session

Participants undergo neuromuscular electrical stimulation (NMES) or functional electrical stimulation (FES) during balance and gait training protocols involving reactive balance tasks and walking tests.

2 sessions including initial screening and experimental training

Trial Site Locations

Total: 1 location

1

University of Illinois at Chicago

Chicago, Illinois, United States, 60612

Actively Recruiting

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Research Team

R

Rudri M Purohit, MS,PT

L

Lakshmi Kannan, MS,PT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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Published Research Related To This Trial