Actively Recruiting
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis
Led by Al-Mustansiriyah University · Updated on 2026-04-23
44
Participants Needed
2
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis. Periodontitis is a chronic inflammatory disease that destroys tooth-supporting tissues. Smoking is a significant risk factor that worsens periodontal destruction and reduces the effectiveness of standard therapies. * The trial is a non-randomized comparative clinical study. * It includes 44 adult patients diagnosed with Stage II and III periodontitis. * The participants are divided into two equal groups: 22 current smokers and 22 non-smokers. * Participants will undergo a baseline examination, followed by standardized non-surgical periodontal therapy consisting of scaling and root planing. * A follow-up visit will be conducted six weeks post-therapy to repeat clinical measurements and saliva collection. * The primary objective is to evaluate changes in salivary biomarker levels and clinical parameters (Plaque Index, Gingival Index, bleeding on probing, Probing Pocket Depth, Clinical Attachment Level) after treatment.
CONDITIONS
Official Title
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Systemically healthy.
- Diagnosed with Stage II and III periodontitis.
- Presence of ≥ 20 teeth (excluding third molars).
- Current smoker OR non-smoker
You will not qualify if you...
- Presence of systemic diseases affecting the periodontium.
- Use of medications affecting inflammation.
- Received periodontal therapy in the past 6 months.
- Received antibiotic therapy in the last 3 months.
- Alcohol use.
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Al-Sadr Specialized Dental Center
Baghdad, Baghdad Governorate, Iraq, 10001
Actively Recruiting
2
Sadr Specialized Dental Center
Baghdad, Baghdad Governorate, Iraq
Actively Recruiting
Research Team
H
Hussein Abdul-Rassul Hatiem, B.D.S., M.Sc. Student
CONTACT
G
Ghasaq Asim Abdulwahab, B.D.S., M.Sc., Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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