Actively Recruiting
Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
Led by M.D. Anderson Cancer Center · Updated on 2026-02-13
87
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To learn about the effectiveness of taking the antipsychotic medication olanzapine to help lower opioid craving.
CONDITIONS
Official Title
Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of cancer pain
- Receiving long-term opioid therapy (7 days or more)
- Active use of opioids within the past 7 days
- Opioid misuse behavior (COMM score 9 or higher out of 68)
- Seen by a Supportive Care Clinic or Pain Clinic clinician
- ECOG performance status 2 or higher out of 4
- Ability to communicate in English
- Ability to understand and willingness to sign a written informed consent document
You will not qualify if you...
- Allergic to or contraindicated for olanzapine
- Current use of any antipsychotic medication (e.g., quetiapine, haloperidol, risperidone)
- History of opioid use disorder or other substance use disorders except marijuana
- History of bipolar disorder, schizophrenia, major depressive disorder, or anorexia nervosa
- Hepatic insufficiency (ALT or AST more than 3 times the highest normal value, or total bilirubin more than 1.5 times the highest normal value) within the past month
- History of uncontrolled diabetes mellitus or high blood sugar (fasting 200 mg/dL or higher) within the past month
- History of seizure disorder or neuroleptic malignant syndrome
- History of cardiac disease (e.g., coronary artery disease, congestive heart failure)
- Known pregnancy in females; females of childbearing potential will be advised to use contraception as usual care
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
J
Joseph Arthur, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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