Effect of Oliceridine Analgesia on Postoperative Nause and Vomiting in Laparoscopic Colorectal Surgery: A Randomized Trial

What this Trial Is About

Postoperative nausea and vomiting (PONV) commonly occur after surgery and can delay recovery. Patients undergoing laparoscopic colorectal surgery face a higher risk of PONV due to factors like pneumoperitoneum, gastrointestinal interruption, delayed oral feeding, nasogastric catheterization, and opioid pain control. Researchers are studying whether oliceridine, a novel selective µ-opioid agonist that activates G protein signaling but less so β-arrestin recruitment, can reduce PONV compared to morphine in these patients. This trial compares two patient-controlled intravenous analgesia treatments given immediately after surgery: oliceridine and morphine. Both drugs are delivered using pumps programmed to provide 2-ml boluses with a 10-minute lockout interval and a background infusion rate of 1 ml per hour, used for three days post-surgery. The doses are 15 mg oliceridine diluted to 100 ml and 50 mg morphine diluted to 100 ml. Participants will be monitored for up to 72 hours after surgery to track the incidence of PONV, vomiting, nausea intensity, and pain levels at rest and with movement. Quality of recovery will be assessed at 24 and 72 hours, and time to first flatus within five days will be recorded. This randomized, triple-blind trial aims to provide detailed safety and efficacy information during the critical postoperative period.

Effect of Oliceridine Analgesia on Postoperative Nause and Vomiting